beta-cell neogenesis in type 2 diabetes.

Jones, Lucy C. ORCID: https://orcid.org/0000-0002-3872-4376 and Clark, Anne 2001. beta-cell neogenesis in type 2 diabetes. Diabetes 50 (1) , S186. 10.2337/diabetes.50.2007.S186

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Abstract

Type 2 diabetes is associated with inappropriate insulin secretion at diagnosis; whether this is due to a decrease in beta-cell mass is unclear. Morphological studies of postmortem specimens have demonstrated a relatively small change or no change in the population of beta-cells, with the most dramatic change being a 30% reduction (1–3). Some of the reduction in mass of beta-cells arises from the destructive effects of islet amyloid fibrils (4). However, it remains to be shown if type 2 diabetes is associated with quantitative or qualitative (functional) changes in islet beta-cells.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine
Publisher:	American Diabetes Association
ISSN:	0012-1797
Last Modified:	22 Jan 2024 13:45
URI:	https://orca.cardiff.ac.uk/id/eprint/165626

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