Incremental induction of NMDAR-STP and NMDAR-LTP in the CA1 area of ventral hippocampal slices relies on graded activation of discrete NMDA receptors

Ingram, Rachael, Volianskis, Rasa, Georgiou, John, Jane, David E., Michael-Titus, Adina T., Collingridge, Graham L. and Volianskis, Arturas 2024. Incremental induction of NMDAR-STP and NMDAR-LTP in the CA1 area of ventral hippocampal slices relies on graded activation of discrete NMDA receptors. Philosophical Transactions of the Royal Society B: Biological Sciences 379 (1906) , 20230239. 10.1098/rstb.2023.0239

Preview

PDF - Published Version Available under License Creative Commons Attribution. Download (1MB) | Preview

Abstract

N-methyl-D-aspartate receptor (NMDAR)-dependent short- and long-term types of potentiation (STP and LTP, respectively) are frequently studied in the CA1 area of dorsal hippocampal slices (DHS). Far less is known about the NMDAR-dependence of STP and LTP in ventral hippocampal slices (VHS), where both types of potentiation are smaller in their magnitude than in the DHS. Here, we first briefly review our knowledge about the NMDARdependence of STP and LTP, and some other forms of synaptic plasticity. We then show in new experiments, that the decay of NMDAR-STP in VHS, similar to dorsal hippocampal NMDAR-STP, is not time- but activity-dependent. We also demonstrate that the induction of submaximal levels of NMDAR-STP and NMDAR-LTP in VHS differs from the induction of saturated levels of plasticity in terms of their sensitivity to subunit-preferring NMDAR antagonists. These data suggest that activation of distinct NMDAR subtypes in a population of neurons results in an incremental increase in the induction of different phases of potentiation with changing sensitivity to pharmacological agents. Differences in pharmacological sensitivity, which arise due to differences in the levels of agonist-evoked biological response, might explain the disparity of the results concerning NMDAR subunit involvement in the induction of NMDAR-dependent plasticity.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Biosciences
Publisher:	The Royal Society
ISSN:	0962-8436
Date of First Compliant Deposit:	24 April 2024
Date of Acceptance:	12 April 2024
Last Modified:	10 Jun 2024 12:30
URI:	https://orca.cardiff.ac.uk/id/eprint/168349

Actions (repository staff only)

Edit Item