Iron(II)‐catalyzed hydrophosphination of isocyanates

Sharpe, Helen R., Geer, Ana M., Lewis, William, Blake, Alexander J. and Kays, Deborah L. ORCID: https://orcid.org/0000-0002-4616-6001 2017. Iron(II)‐catalyzed hydrophosphination of isocyanates. Angewandte Chemie International Edition 56 (17) , pp. 4845-4848. 10.1002/anie.201701051

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Abstract

The first transition metal catalyzed hydrophosphination of isocyanates is presented. The use of low-coordinate iron(II) precatalysts leads to an unprecedented catalytic double insertion of isocyanates into the P−H bond of diphenylphosphine to yield phosphinodicarboxamides [Ph2PC(=O)N(R)C(=O)N(H)R], a new family of derivatized organophosphorus compounds. This remarkable result can be attributed to the low-coordinate nature of the iron(II) centers whose inherent electron deficiency enables a Lewis-acid mechanism in which a combination of the steric pocket of the metal center and substrate size determines the reaction products and regioselectivity.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Chemistry
Publisher:	Wiley
ISSN:	1433-7851
Last Modified:	11 Jul 2024 15:45
URI:	https://orca.cardiff.ac.uk/id/eprint/170337

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