The effectiveness of conservative interventions on pain, function, and quality of life in adults with hypermobile Ehlers-Danlos Syndrome/Hypermobility Spectrum Disorders and shoulder symptoms: A systematic review

Higo, Anna, Palmer, Shea ORCID: https://orcid.org/0000-0002-5190-3264, Liaghat, Behnam, Tallis, Jason, Silvester, Lucy and Pearce, Gemma 2024. The effectiveness of conservative interventions on pain, function, and quality of life in adults with hypermobile Ehlers-Danlos Syndrome/Hypermobility Spectrum Disorders and shoulder symptoms: A systematic review. Archives of Rehabilitation Research and Clinical Translation 6 (3) , 100360. 10.1016/j.arrct.2024.100360

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Abstract

Objective: To synthesise the evidence on conservative interventions for shoulder symptoms in hypermobile Ehlers-Danlos Syndrome and Hypermobility Spectrum Disorders. Data Sources: A literature search was conducted using data sources Medline, PEDro, CINAHL, AMED, Elsevier Scopus, and the Cochrane Library from January 1998 to June 2023. Study Selection: The review included primary empirical research on adults diagnosed with hEDS or HSD who experienced pain and/or mechanical shoulder symptoms and underwent conservative interventions. Initially, 17,565 studies were identified, which reduced to 9,668 after duplicate removal. Following title and abstract screening by two independent authors, 9630 studies were excluded. The full texts of the remaining 38 were assessed and 34 were excluded leaving four articles for examination. Data Extraction: Two authors independently extracted data using a predefined extraction table. Quality assessment utilised the Joanna Briggs Institute checklists and Template for Intervention Description and Replication (TIDieR). Data Synthesis: The review covered four studies with a total of seven conservative interventions, including exercise programmes, kinesiology taping and elasticised compression orthoses. Standardised Mean Differences (SMDs) were calculated to inform intervention effects over time. Duration of interventions ranged from 48 hours to 24 weeks, showing positive effect sizes over time concerning the Western Ontario Shoulder Instability Index (WOSI), pain levels, improved function in activities of daily living, and isometric and isokinetic strength. Small to negligible effect sizes were found for kinesiophobia during completion of exercise programmes. Conclusion: Shoulder symptoms in hEDS/HSD are common yet significant gaps in knowledge remain regarding conservative interventions, preventing optimal evidence-based application for clinicians. Further research is necessary to explore the most effective intervention types, frequencies, dosages, and delivery methods tailored to the specific requirements of this patient population.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Healthcare Sciences
Publisher:	Elsevier
ISSN:	2590-1095
Date of First Compliant Deposit:	29 July 2024
Date of Acceptance:	15 July 2024
Last Modified:	02 Oct 2024 14:37
URI:	https://orca.cardiff.ac.uk/id/eprint/170680

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