Electrocatalytic continuous flow chlorinations with iodine(I/III) mediators

Patra, Tuhin, Arepally, Sagar, Seitz, Jakob and Wirth, Thomas ORCID: https://orcid.org/0000-0002-8990-0667 2024. Electrocatalytic continuous flow chlorinations with iodine(I/III) mediators. Nature Communications 15 (1) , 6329. 10.1038/s41467-024-50643-z

	PDF - Published Version Download (14MB)
	PDF - Supplemental Material Download (299kB)

Abstract

Electrochemistry offers tunable, cost effective and environmentally friendly alternatives to carry out redox reactions with electrons as traceless reagents. The use of organoiodine compounds as electrocatalysts is largely underdeveloped, despite their widespread application as powerful and versatile reagents. Mechanistic data reveal that the hexafluoroisopropanol assisted iodoarene oxidation is followed by a stepwise chloride ligand exchange for the catalytic generation of the dichloroiodoarene mediator. Here, we report an environmentally benign iodine(I/III) electrocatalytic platform for the in situ generation of dichloroiodoarenes for different reactions such as mono- and dichlorinations as well as chlorocyclisations within a continuous flow setup.

Item Type:	Article
Date Type:	Published Online
Status:	Published
Schools:	Chemistry
Additional Information:	License information from Publisher: LICENSE 1: URL: http://creativecommons.org/licenses/by/4.0/, Type: open-access
Publisher:	Nature Research
ISSN:	2041-1723
Funders:	EPSRC
Date of First Compliant Deposit:	29 July 2024
Date of Acceptance:	17 July 2024
Last Modified:	20 Aug 2024 15:51
URI:	https://orca.cardiff.ac.uk/id/eprint/170981

Actions (repository staff only)

Edit Item