How to distinguish non-inflammatory from inflammatory pain in RA?

Khot, Sharmila ORCID: https://orcid.org/0000-0003-4677-5680, Tackley, George ORCID: https://orcid.org/0000-0002-7464-7662 and Choy, Ernest ORCID: https://orcid.org/0000-0003-4459-8609 2024. How to distinguish non-inflammatory from inflammatory pain in RA? Current Rheumatology Reports 26 , pp. 403-413. 10.1007/s11926-024-01159-4

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Abstract

Purpose of the Review Managing non-inflammatory pain in rheumatoid arthritis (RA) can be a huge burden for the rheumatologist. Pain that persists despite optimal RA treatment is extremely challenging for patient and physician alike. Here, we outline the latest research relevant to distinguishing non-inflammatory from inflammatory RA pain and review the current understanding of its neurobiology and management. Recent Findings Nociplastic pain is a recently introduced term by the international pain community. Its definition encompasses the non-inflammatory pain of RA and describes pain that is not driven by inflamed joints or compromised nerves, but that is instead driven by a functional reorganisation of the central nervous system (CNS). Summary Insights from all areas of nociplastic pain research, including fibromyalgia, support a personalised pain management approach for non-inflammatory pain of RA, with evidence-based guidelines favouring use of non-pharmacological interventions. Future developments include novel CNS targeting pharmacotherapeutic approaches to treat nociplastic pain.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Schools > Psychology Research Institutes & Centres > Cardiff University Brain Research Imaging Centre (CUBRIC)
Publisher:	Current Medicine Group
ISSN:	1523-3774
Date of First Compliant Deposit:	16 August 2024
Date of Acceptance:	17 July 2024
Last Modified:	06 Dec 2024 22:22
URI:	https://orca.cardiff.ac.uk/id/eprint/171290

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