A cluster-randomised controlled feasibility trial evaluating the Cognitive Occupation-Based programme for people with Multiple Sclerosis (COB-MS)

Hynes, Sinéad M., Dwyer, Christopher P., Alvarez-Iglesias, Alberto, Rogers, Fionnuala, Joyce, Robert A., Oglesby, Megan H., Moses, Anusha, Bane, Eimear, Counihan, Timothy J. and Charamba, Beatrice 2024. A cluster-randomised controlled feasibility trial evaluating the Cognitive Occupation-Based programme for people with Multiple Sclerosis (COB-MS). Neurological Sciences 10.1007/s10072-024-07757-5

Preview

PDF - Published Version Available under License Creative Commons Attribution. Download (829kB) | Preview

Abstract

Introduction There is a high prevalence of cognitive difficulties in MS, but despite this, there are few programmes targeting cognition that focus on the ability to function well in everyday life. The Cognitive Occupation-Based programme for people with Multiple Sclerosis (COB-MS), an occupation-focused cognitive intervention, was developed to address this. It addresses both the functional difficulties and the wide-ranging symptoms that present in MS. Objective Here we report on the results of a cluster-randomised controlled feasibility trial (ISRCTN11462710; registered 4th September 2019) evaluating the COB-MS in terms of feasibility and initial efficacy as a cognitive intervention for people with MS. Method The eight-session COB-MS intervention was delivered remotely by occupational therapists to participants with MS in the intervention group. Following the end of the trial the COB-MS was delivered to the wait-list control group. Data was collected from people with MS experiencing cognitive difficulties at baseline, post-intervention, 12-weeks, and 6-month follow-up. The primary outcome measure was the Goal Attainment Scaling at 12 weeks. Data was also collected in the domains of cognition, quality of life, and mood. Results One hundred and eighteen people with MS and cognitive difficulties were randomised to either usual care (n = 60) or COB-MS intervention (n = 58). Ninety-four participants were retained at 6-month follow-up. The COB-MS was found to be feasible, including trial procedures and protocol. Data indicates that the COB-MS is accepted by participants and had positive impacts on daily life. Those allocated to the COB-MS group had a significant improvement in the primary outcome compared to the control condition. Progression criteria set for the feasibility trial have been met therefore further testing of the COB-MS at a definitive trial is supported by the results. Conclusion The results provide a strong basis for a pathway to a future definitive trial of COB-MS, with respect to both feasibility and preliminary, clinical efficacy.

Item Type:	Article
Date Type:	Published Online
Status:	In Press
Schools:	Psychology
Publisher:	Springer
ISSN:	1590-1874
Date of First Compliant Deposit:	27 September 2024
Date of Acceptance:	2 September 2024
Last Modified:	02 Oct 2024 13:01
URI:	https://orca.cardiff.ac.uk/id/eprint/172423

Actions (repository staff only)

Edit Item