In vivo hippocampal subfield volumes in bipolar disorder—A mega-analysis from The Enhancing Neuro Imaging Genetics through Meta-Analysis Bipolar Disorder Working Group

Haukvik, Unn K., Gurholt, Tiril P., Nerland, Stener, Elvsåshagen, Torbjørn, Akudjedu, Theophilus N., Alda, Martin, Alnæs, Dag, Alonso-Lana, Silvia, Bauer, Jochen, Baune, Bernhard T., Benedetti, Francesco, Berk, Michael, Bettella, Francesco, Bøen, Erlend, Bonnín, Caterina M., Brambilla, Paolo, Canales?Rodríguez, Erick J., Cannon, Dara M., Caseras, Xavier ORCID: https://orcid.org/0000-0002-8490-6891, Dandash, Orwa, Dannlowski, Udo, Delvecchio, Giuseppe, Díaz?Zuluaga, Ana M., van Erp, Theo G. M., Fatjó?Vilas, Mar, Foley, Sonya F., Förster, Katharina, Fullerton, Janice M., Goikolea, José M., Grotegerd, Dominik, Gruber, Oliver, Haarman, Bartholomeus C. M., Haatveit, Beathe, Hajek, Tomas, Hallahan, Brian, Harris, Mathew, Hawkins, Emma L., Howells, Fleur M., Hülsmann, Carina, Jahanshad, Neda, Jørgensen, Kjetil N., Kircher, Tilo, Krämer, Bernd, Krug, Axel, Kuplicki, Rayus, Lagerberg, Trine V., Lancaster, Thomas M., Lenroot, Rhoshel K., Lonning, Vera, López?Jaramillo, Carlos, Malt, Ulrik F., McDonald, Colm, McIntosh, Andrew M., McPhilemy, Genevieve, van der Meer, Dennis, Melle, Ingrid, Melloni, Elisa M. T., Mitchell, Philip B., Nabulsi, Leila, Nenadi?, Igor, Oertel, Viola, Oldani, Lucio, Opel, Nils, Otaduy, Maria C. G., Overs, Bronwyn J., Pineda?Zapata, Julian A., Pomarol?Clotet, Edith, Radua, Joaquim, Rauer, Lisa, Redlich, Ronny, Repple, Jonathan, Rive, Maria M., Roberts, Gloria, Ruhe, Henricus G., Salminen, Lauren E., Salvador, Raymond, Sarró, Salvador, Savitz, Jonathan, Schene, Aart H., Sim, Kang, Soeiro?de?Souza, Marcio G., Stäblein, Michael, Stein, Dan J., Stein, Frederike, Tamnes, Christian K., Temmingh, Henk S., Thomopoulos, Sophia I., Veltman, Dick J., Vieta, Eduard, Waltemate, Lena, Westlye, Lars T., Whalley, Heather C., Sämann, Philipp G., Thompson, Paul M., Ching, Christopher R. K., Andreassen, Ole A. and Agartz, Ingrid 2022. In vivo hippocampal subfield volumes in bipolar disorder—A mega-analysis from The Enhancing Neuro Imaging Genetics through Meta-Analysis Bipolar Disorder Working Group. Human Brain Mapping 43 (1) , pp. 385-398. 10.1002/hbm.25249

Preview

PDF - Published Version Available under License Creative Commons Attribution. Download (1MB) | Preview

Abstract

The hippocampus consists of anatomically and functionally distinct subfields that may be differentially involved in the pathophysiology of bipolar disorder (BD). Here we, the Enhancing NeuroImaging Genetics through Meta-Analysis Bipolar Disorder workinggroup, study hippocampal subfield volumetry in BD. T1-weighted magnetic resonance imaging scans from 4,698 individuals (BD = 1,472, healthy controls [HC] = 3,226) from 23 sites worldwide were processed with FreeSurfer. We used linear mixed-effects models and mega-analysis to investigate differences in hippocampal subfield volumes between BD and HC, followed by analyses of clinical characteristics and medication use. BD showed significantly smaller volumes of the whole hippocampus (Cohen's d = −0.20), cornu ammonis (CA)1 (d = −0.18), CA2/3 (d = −0.11), CA4 (d = −0.19), molecular layer (d = −0.21), granule cell layer of dentate gyrus (d = −0.21), hippocampal tail (d = −0.10), subiculum (d = −0.15), presubiculum (d = −0.18), and hippocampal amygdala transition area (d = −0.17) compared to HC. Lithium users did not show volume differences compared to HC, while non-users did. Antipsychotics or antiepileptic use was associated with smaller volumes. In this largest study of hippocampal subfields in BD to date, we show widespread reductions in nine of 12 subfields studied. The associations were modulated by medication use and specifically the lack of differences between lithium users and HC supports a possible protective role of lithium in BD.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine
Publisher:	Wiley
ISSN:	1065-9471
Date of First Compliant Deposit:	22 October 2024
Date of Acceptance:	6 October 2020
Last Modified:	22 Oct 2024 10:27
URI:	https://orca.cardiff.ac.uk/id/eprint/173239

Actions (repository staff only)

Edit Item