Molecular mechanism of bone metastasis in Breast Cancer

Sui, Laijian, Wang, Jing, Jiang, Wen G. ORCID: https://orcid.org/0000-0002-3283-1111, Song, Xicheng and Ye, Lin ORCID: https://orcid.org/0000-0002-0303-2409 2024. Molecular mechanism of bone metastasis in Breast Cancer. Frontiers in Oncology 10.3389/fonc.2024.1401113

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Abstract

Bone metastasis is a debilitating complication that frequently occurs in the advanced stages of breast cancer. However, the underlying molecular and cellular mechanisms of the bone metastasis remain unclear. Here, we elucidated how bone metastasis arises from tumor cells that detach from the primary lesions and infiltrate into the surrounding tissue, as well as how these cells disseminate to distant sites. Specifically, we elaborated how tumor cells preferentially grow within the bone micro-environment and interact with bone cells to facilitate bone destruction, characterized as osteoclastic bone metastasis, as well as new bone matrix deposition, characterized as osteoblastic bone metastasis. We also updated the current understanding of the molecular mechanisms underlying bone metastasis and reasons for relapse in breast cancer, and also opportunities of developing novel diagnostic approaches and treatment.

Item Type:	Article
Status:	In Press
Schools:	Medicine
Publisher:	Frontiers Media
Date of Acceptance:	24 October 2024
Last Modified:	12 Nov 2024 11:30
URI:	https://orca.cardiff.ac.uk/id/eprint/173419

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