Retinal ganglion cell subtypes and their vulnerability in glaucoma

Morgan, James E ORCID: https://orcid.org/0000-0002-8920-1065, Bevan, Ryan J ORCID: https://orcid.org/0000-0002-2557-2887 and Cimaglia, Gloria 2024. Retinal ganglion cell subtypes and their vulnerability in glaucoma. Jacobs, T. and Liton, P. B., eds. Glaucoma. Methods and Protocols, Vol. 2858. Methods in Molecular Biology, New York, NY, USA: pp. 191-205. (10.1007/978-1-0716-4140-8_16)

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Abstract

The detection of selective retinal ganglion cell damage in glaucoma has been a long sought-after goal, not just for the development of clinical tests for the early detection of glaucoma but for the elucidation of potential mechanisms underlying retinal ganglion cell loss. Early reports of the selective vulnerability of larger retinal ganglion cells (RGCs) in human studies did not translate simply to the loss of a particular class of RGC but more likely reflected shrinkage and degeneration across all RGC classes. Subsequent studies of nonhuman primate (NHP) models of glaucoma indicated some selectivity with great damage to the magnocellular vs parvocellular pathways. More recently, rodent models of experimental glaucoma have highlighted a selective vulnerability of OFF-centered RGCs-particularly those with transient responses. Selectivity for OFF pathway damage is also seen as a trend in a rat model of glaucoma. These data support the concept that some RGCs are more vulnerable to the effects of glaucoma damage. This chapter covers some of the methods to elucidate RGC damage and the relevance of model selection to mimic human glaucoma rather than just RGC death. [Abstract copyright: © 2025. The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature.]

Item Type:	Book Section
Date Type:	Published Online
Schools:	Optometry and Vision Sciences
ISBN:	9781071641392
Last Modified:	06 Nov 2024 14:00
URI:	https://orca.cardiff.ac.uk/id/eprint/173694

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