The joint memory effect: challenging the selfish stigma in Huntington’s disease?

Dalléry, Romain, Fraisse, Nicolas, Cléret de Langavant, Laurent, Youssov, Katia, Morgado, Graça, Massart, Renaud, Schubert, Robin, Reilmann, Ralf, Jacquemot, Charlotte, Bapst, Blanche, Busse, Monica ORCID: https://orcid.org/0000-0002-5331-5909, Craufurd, David, Rosser, Anne ORCID: https://orcid.org/0000-0002-4716-4753, Lunven, Marine and Bachoud-Lévi, Anne-Catherine 2024. The joint memory effect: challenging the selfish stigma in Huntington’s disease? Brain Communications 10.1093/braincomms/fcae440

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Abstract

The prevalent belief that individuals with Huntington’s disease exhibit selfish behaviour, disregarding the thoughts, feelings, and actions of others, has been challenged by patient organizations and clinical experts. To further investigate this issue and study whether participants with Huntington's disease can pay attention to others, a joint memory task was carried out in patients with Huntington's disease with and without a partner. This study involved 69 participants at an early stage of Huntington’s disease and 56 healthy Controls from the UK, France, and Germany, who participated in the international Repair-HD multicentre study (NCT03119246). Participants completed a semantic categorization task across three categories: animals, fruits and vegetables, and manufactured objects. They performed the task either alone (Alone condition) or with the examiner acting as a partner (Pair condition). In the Pair condition, the participant was assigned one category, their partner another, and one category was left unassigned. Afterward, participants engaged in a surprise free-recall task to remember as many words as possible. Words not assigned to anyone were considered socially irrelevant in contrast to the ones assigned to the participant and to the partner. Both groups demonstrated the expected Self-Prioritization Effect, recalling their assigned words better than their partner's or unassigned words in both conditions. Additionally, a Joint-Memory Effect was observed, with better recall for the partner's assigned words than the unassigned words in the Pair condition (Controls: difference = 0.45, p < 0.001; Huntington’s disease participants: difference = 0.34, p < 0.001). Socially-relevant words were thus better recalled than irrelevant words. The number of recalled words correlated with cognitive performance (all p-values < 0.05) and MRI analysis revealed a negative correlation between the Joint Memory Effect and right orbitofrontal grey matter density in Huntington’s disease participants. These findings challenge the notion that individuals with Huntington’s disease display selfish behaviours because of disinterest in others. They show the ability to process information about their partners, implying that their social difficulties may arise from factors other than social cognition deficits. This opens the door for more ecological assessments of social cognition in Huntington's disease patients.

Item Type:	Article
Date Type:	Published Online
Status:	In Press
Schools:	Medicine
Additional Information:	License information from Publisher: LICENSE 1: URL: https://creativecommons.org/licenses/by/4.0/, Start Date: 2024-12-09
Publisher:	Oxford University Press
Date of First Compliant Deposit:	6 January 2025
Date of Acceptance:	6 December 2024
Last Modified:	15 Jan 2025 12:14
URI:	https://orca.cardiff.ac.uk/id/eprint/175001

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