Raman study of intermediates formed during the electrochemical N-nitrosation of secondary amines

Richardson, Scott, Babaahmadi, Rasool, Edwards, Lee E. ORCID: https://orcid.org/0000-0003-2200-9578, Ali, Rojan, Melen, Rebecca L. ORCID: https://orcid.org/0000-0003-3142-2831, Roy, Debdulal and Wirth, Thomas ORCID: https://orcid.org/0000-0002-8990-0667 2025. Raman study of intermediates formed during the electrochemical N-nitrosation of secondary amines. Chemistry ‐ Methods , e202400067. 10.1002/cmtd.202400067

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Abstract

An in situ electrochemical Raman method is described to identify and validate the reaction pathway of amine nitrosations using density functional theory (DFT). In this reaction, sodium nitrite is used as an affordable and readily available nitrosating reagent, which also serves as an electrolyte in the reaction. This is a green approach towards nitrosations as it does not require the use of acids and other harsh or toxic solvents and chemicals. Intermediate species have been detected using Raman spectroscopy and are correlated with the calculated spectra expected in the reaction pathway to the N-nitrosamine products.

Item Type:	Article
Date Type:	Published Online
Status:	In Press
Schools:	Chemistry Cardiff Catalysis Institute (CCI)
ISSN:	2628-9725
Funders:	Royal Society
Date of First Compliant Deposit:	7 January 2025
Date of Acceptance:	2 December 2024
Last Modified:	08 Jan 2025 12:30
URI:	https://orca.cardiff.ac.uk/id/eprint/175055

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