Bacterial metabolic 'toxins': A new mechanism for lactose and food intolerance, and irritable bowel syndrome

Campbell, Anthony Keith, Matthews, Stephanie Beatrix, Vassel, Nasrin, Cox, Charles D., Naseem, Riffat, Chaichi, J., Holland, I. B., Green, John Trevor and Wann, Kenneth Taylor 2010. Bacterial metabolic 'toxins': A new mechanism for lactose and food intolerance, and irritable bowel syndrome. Toxicology 278 (3) , pp. 268-276. 10.1016/j.tox.2010.09.001

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Abstract

Lactose and food intolerance cause a wide range of gut and systemic symptoms, including gas, gut pain, diarrhoea or constipation, severe headaches, severe fatigue, loss of cognitive functions such as concentration, memory and reasoning, muscle and joint pain, heart palpitations, and a variety of allergies ( [Matthews and Campbell, 2000], [Matthews et al., 2005] and [Waud et al., 2008]). These can be explained by the production of toxic metabolites from gut bacteria, as a result of anaerobic digestion of carbohydrates and other foods, not absorbed in the small intestine. These metabolites include alcohols, diols such as butan 2,3 diol, ketones, acids, and aldehydes such as methylglyoxal ( [Campbell et al., 2005] and [Campbell et al., 2009]). These ‘toxins’ induce calcium signals in bacteria and affect their growth, thereby acting to modify the balance of microflora in the gut ( [Campbell et al., 2004], [Campbell et al., 2007a] and [Campbell et al., 2007b]). These bacterial ‘toxins’ also affect signalling mechanisms in cells around the body, thereby explaining the wide range of symptoms in people with food intolerance. This new mechanism also explains the most common referral to gastroenterologists, irritable bowel syndrome (IBS), and the illness that afflicted Charles Darwin for 50 years ( [Campbell and Matthews, 2005a] and [Campbell and Matthews, 2005b]). We propose it will lead to a new understanding of the molecular mechanism of type 2 diabetes and some cancers.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Pharmacy Medicine
Subjects:	R Medicine > RC Internal medicine
Uncontrolled Keywords:	Bacteria; Toxin; Lactose; Irritable bowel syndrome; Calcium
Additional Information:	Special Issue: Highlights of the 2010 Annual Congress of The British Toxicology Society. Includes the Abstracts of the British Toxicology Society, Spring 2010
Publisher:	Elsevier
ISSN:	0300-483X
Last Modified:	06 Jan 2018 20:18
URI:	https://orca.cardiff.ac.uk/id/eprint/17584

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