Transient cortical beta-frequency oscillations associated with contextual novelty in high density mouse EEG

Walsh, Callum, Tait, Luke, Garrido, Maria Garcia, Brown, Jonathan T. and Ridler, Thomas 2025. Transient cortical beta-frequency oscillations associated with contextual novelty in high density mouse EEG. Scientific Reports 15 (1) , 2897. 10.1038/s41598-025-86008-9

Preview

PDF - Published Version Available under License Creative Commons Attribution. Download (3MB) | Preview

Abstract

Beta-frequency oscillations (20–30 Hz) are prominent in both human and rodent electroencephalogram (EEG) recordings. Discrete epochs of beta (or Beta2) oscillations are prevalent in the hippocampus and other brain areas during exploration of novel environments. However, little is known about the spatial distribution and temporal relationships of beta oscillations across the cortex in response to novel contexts. To investigate this, mice fitted with 30-channel EEG-style multi-electrode arrays underwent a single recording session in a novel environment. While changes to spectral properties of cortical oscillations were minimal, there was a profound increase in the rate of beta bursts during the initial part of the recording session, when the environment was most novel. This was true across the cortex but most notable in recording channels situated above the retrosplenial cortex. Additionally, novelty was associated with greater connectivity between retrosplenial areas and the rest of the cortex, specifically in the beta frequency range. However, it was also found that the cortex in general, is highly modulated by environmental novelty. This data further suggests the retrosplenial cortex is an important hub for distinguishing environmental context and highlights the diversity of functions for beta oscillations across the brain, which can be observed using high-density EEG.

Item Type:	Article
Date Type:	Published Online
Status:	Published
Schools:	Psychology Cardiff University Brain Research Imaging Centre (CUBRIC)
Publisher:	Nature Research
ISSN:	2045-2322
Date of First Compliant Deposit:	4 February 2025
Date of Acceptance:	7 January 2025
Last Modified:	12 Feb 2025 14:01
URI:	https://orca.cardiff.ac.uk/id/eprint/175911

Actions (repository staff only)

Edit Item