Mishra, Pawan  ORCID: https://orcid.org/0000-0003-1141-3487, Hind, Jasmine, Fallis, Ian A. ORCID: https://orcid.org/0000-0001-7361-0182 and Tredwell, Matthew ORCID: https://orcid.org/0000-0002-4184-5611
2025.
Radiochemical synthesis of alkyl geminal 18F-difluoroalkyl motifs mediated by silver(I) oxide.
Organic Letters
27
(7)
, pp. 1724-1728.
10.1021/acs.orglett.5c00187
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License URL: http://creativecommons.org/licenses/by/4.0/
License Start date: 6 February 2025
Official URL: http://dx.doi.org/10.1021/acs.orglett.5c00187
Abstract
18F radiotracers are used in positron emission tomography imaging for medical diagnosis and drug development. Current methods to synthesize 18F-polyfluorinated functional groups are limited in substrate scope and result in radiotracers with low molar activities (Am). We disclose the synthesis of a range of 18F-difluoroalkyl groups by nucleophilic substitution of geminal bromofluoroalkyl electrophiles with [18F]fluoride mediated by Ag2O. The utility of this transformation to support (pre)clinical imaging is demonstrated by translation to an automated synthesizer.
| Item Type: | Article |
|---|---|
| Date Type: | Publication |
| Status: | Published |
| Schools: | Schools > Chemistry |
| Publisher: | American Chemical Society |
| ISSN: | 1523-7060 |
| Funders: | EPSRC |
| Date of First Compliant Deposit: | 14 February 2025 |
| Date of Acceptance: | 4 February 2025 |
| Last Modified: | 24 Mar 2025 17:00 |
| URI: | https://orca.cardiff.ac.uk/id/eprint/176015 |
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