Luminescent Ru(II) complexes based on functionalised 1,10-phenanthroline derivatised ligands towards bioconjugated probes

Ibbott, Alexandra R., Miquel Fosco, Paula, Alenazy, Deemah M. and Pope, Simon J.A. ORCID: https://orcid.org/0000-0001-9110-9711 2025. Luminescent Ru(II) complexes based on functionalised 1,10-phenanthroline derivatised ligands towards bioconjugated probes. Inorganica Chimica Acta 579 , 122561. 10.1016/j.ica.2025.122561

Preview

PDF - Published Version Available under License Creative Commons Attribution. Download (1MB) | Preview

Abstract

A series of photoluminescent, heteroleptic [Ru(bipy)2(Ln)](PF6)2 (2,2′-bipyridine = bipy; Ln = 1,10-phenanthroline derivative) analogues have been prepared. Within the series of complexes the structural variation is provided by the ancillary ligand, Ln, which is based upon a 5-substituted 1,10-phenanthroline species. The synthesis of the ligands was achieved in two steps from 5,6-epoxy-5,6-dihydro-1,10-phenanthroline allowing a range of different morpholine, piperazine and piperidine derivatives to be attached to the 1,10-phenanthroline core at the 5-position. Furthermore, the synthetic utility of the piperazine derivative (L1) was demonstrated by bioconjugating a cholesteryl moiety to the ligand (yielding L8). Following complexation, the isolated Ru(II) complexes show classical 3MLCT characteristics with phosphorescent emission at 605–610 nm.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Chemistry
Publisher:	Elsevier
ISSN:	0020-1693
Funders:	EPSRC
Date of First Compliant Deposit:	7 February 2025
Date of Acceptance:	21 January 2025
Last Modified:	14 Feb 2025 14:21
URI:	https://orca.cardiff.ac.uk/id/eprint/176029

Actions (repository staff only)

Edit Item