Folate-conjugated zein/Fe3O4 nanocomplexes for the enhancement of cellular uptake and cytotoxicity of gefitinib

Pang, Jiafeng, Li, Zhixian, Li, Shaomin, Lin, Shuying, Wang, Hongdi, Xie, Qiuling and Jiang, Yanbin 2018. Folate-conjugated zein/Fe3O4 nanocomplexes for the enhancement of cellular uptake and cytotoxicity of gefitinib. Journal of Materials Science 53 (21) , pp. 14907-14921. 10.1007/s10853-018-2684-7

Full text not available from this repository.

Abstract

Integrating various functional components into a single nano-platform is an ideal but challenging strategy for cancer therapy. Herein, a facile approach to fabricating multi-targeted nano-drug delivery systems which can be monitored is reported. Superparamagnetic iron oxide nanoparticles (SPIONs) and gefitinib (GEF) were encapsulated into folic acid-conjugated zein (Fa–zein) nanocomplexes (GEF-FSZs) with good dispersity, high GEF loading efficiency and pH-dependent release profile. The uptake of water-insoluble GEF was facilitated by encapsulating GEF into a zein-based nanocomplex, the magnetic responsive property endowed by SPIONs and the conjugation of Fa, which resulted in enhanced toxicity to A549 cells. The endocytosis study indicated that macropinocytosis and clathrin/caveolae-independent endocytosis exerted great influence on the internalization of GEF-FSZs. These results implied that GEF-FSZs could be a promising candidate for controlled and targeted drug delivery.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Schools > Engineering
Publisher:	Springer
ISSN:	0022-2461
Date of Acceptance:	10 July 2018
Last Modified:	28 Feb 2025 14:30
URI:	https://orca.cardiff.ac.uk/id/eprint/176451

Actions (repository staff only)

Edit Item