Tandem reductive amination and deuteration over a phosphorus-modified iron center.

Qi, Haifeng, Jiao, Yueyue, Duan, Jianglin, Dummer, Nicholas F. ORCID: https://orcid.org/0000-0002-0946-6304, Zhang, Bin, Ren, Yujing, Taylor, Stuart H. ORCID: https://orcid.org/0000-0002-1933-4874, Qin, Yong, Junge, Kathrin, Jiao, Haijun, Hutchings, Graham J. ORCID: https://orcid.org/0000-0001-8885-1560 and Beller, Matthias 2025. Tandem reductive amination and deuteration over a phosphorus-modified iron center. Nature Communications 16 (1) , 1840. 10.1038/s41467-024-55722-9

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Abstract

Deuterated amines are key building blocks for drug synthesis and the identification of metabolites of new pharmaceuticals, which drives the search for general, efficient, and widely applicable methods for the selective synthesis of such compounds. Here, we describe a multifunctional phosphorus-doped carbon-supported Fe catalyst with highly dispersed isolated metal sites that allow for tandem reductive amination-deuteration sequences. The optimal phosphorus-modified Fe-based catalyst shows excellent performance in terms of both reactivity and regioselectivity for a wide range of deuterated anilines, amines, bioactive complexes, and drugs (>50 examples). Experiments on the gram scale and on catalyst recycling show the application potential of this method. Beyond the direct applicability of the developed method, the described approach opens a perspective for the development of multifunctional single-atom catalysts in other value-adding organic syntheses.

Item Type:	Article
Date Type:	Published Online
Status:	Published
Schools:	Research Institutes & Centres > Cardiff Catalysis Institute (CCI) Schools > Chemistry
Additional Information:	License information from Publisher: LICENSE 1: Title: cc by-nc-nd, Type: cc by-nc-nd
Publisher:	Nature Research
Date of First Compliant Deposit:	5 March 2025
Date of Acceptance:	20 December 2024
Last Modified:	14 Mar 2025 10:24
URI:	https://orca.cardiff.ac.uk/id/eprint/176640

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