Osteopontin expression profiles predict pathological and clinical outcome in breast cancer

Patani, Neill, Jouhra, Fadi, Jiang, Wen Guo ORCID: https://orcid.org/0000-0002-3283-1111 and Mokbel, Kefah 2008. Osteopontin expression profiles predict pathological and clinical outcome in breast cancer. Anticancer Research 28 (6B) , pp. 4105-4110.

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Abstract

Background: Osteopontin (OPN) overexpression in breast cancer has been associated with adverse pathological and clinical outcomes. In this study, the OPN expression profiles were examined in a cohort of breast cancer patients. Patients and Methods: RNA extraction and reverse transcription were performed on breast carcinomas (n=127) and normal tissues (n=33). Transcript levels were determined using real-time PCR. Results: The OPN-a levels decreased with increasing TNM stage and worse clinical outcome. The OPN-b levels increased with tumour grade and Nottingham Prognostic Index (NPI) stage, were higher in patients who died of breast cancer than in those who were disease-free after 10 years and predicted disease-free survival. The OPN-c expression was associated with tumour grade and poor prognosis. Furthermore, the expression levels predicted local recurrence, disease-free survival and bone metastases. Conclusion: OPN expression profiles are significantly associated with tumour grade, stage and patient prognosis in breast cancer. OPN-c is likely to be of particular utility as a prognostic marker and should be included in future validation studies.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine
Subjects:	R Medicine > RB Pathology R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)
Uncontrolled Keywords:	Breast cancer, osteopontin, mortality, survival
Publisher:	International Institute of Anticancer Research
ISSN:	0250-7005
Last Modified:	18 Oct 2022 14:29
URI:	https://orca.cardiff.ac.uk/id/eprint/17681

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