Middle-aged women with Rett Syndrome: Longitudinal profile from the British Isles Rett Syndrome Survey and suggestions for care

Hryniewiecka-Jaworska, Anna, Sloper, Emily, Archer, Hayley and Clarke, Angus ORCID: https://orcid.org/0000-0002-1200-9286 2025. Middle-aged women with Rett Syndrome: Longitudinal profile from the British Isles Rett Syndrome Survey and suggestions for care. Journal of Applied Research in Intellectual Disabilities 38 (2) , e70051. 10.1111/jar.70051

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Abstract

Background and Methods: We report historical information from longitudinal data held in the British Isles Rett Syndrome Survey (BIRSS) concerning women of at least 40 years. This information, including comments on the quality of care, has been provided by families, carers, and clinicians. Results: Information was available on 30 women with a clinical diagnosis of Rett syndrome (RTT), of whom 24 were < 50 years. Twenty-nine women were diagnosed with classic RTT and one with atypical RTT. Of 18 women tested for MECP2 mutations, pathogenic variants were identified in 14. There was little increase in severity over time. Conclusions: The study found that: (1) milder phenotypes were common; (2) depression may be under-recognised; (3) menopause does not seem to occur early; (4) nutrition standards from the general population will often be inapplicable; (5) multiple opportunities exist to prevent functional decline through detailed attention to the quality of the medical and social care.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Schools > Medicine
Publisher:	Wiley
ISSN:	1360-2322
Date of First Compliant Deposit:	28 March 2025
Date of Acceptance:	20 March 2025
Last Modified:	08 Apr 2025 11:30
URI:	https://orca.cardiff.ac.uk/id/eprint/177254

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