Homelessness, type of homelessness, and risk of cause-specific mortality: A systematic review and meta-analysis of 116 studies comprising 2,563,633 homeless people and 129,292,553 population controls

White, James, Moriarty, Yvonne ORCID: https://orcid.org/0000-0002-7608-4699, Lau, Mandy ORCID: https://orcid.org/0000-0001-5894-570X, Cannings-John, Rebecca ORCID: https://orcid.org/0000-0001-5235-6517, Palmer, Abigail, Weightman, Alison L. ORCID: https://orcid.org/0000-0001-5210-3798, Kiseleva, M. ORCID: https://orcid.org/0000-0002-1994-6678 and Batty, G. David 2025. Homelessness, type of homelessness, and risk of cause-specific mortality: A systematic review and meta-analysis of 116 studies comprising 2,563,633 homeless people and 129,292,553 population controls. [Online]. Preprints with The Lancet: Elsevier. Available at: https://doi.org/10.2139/ssrn.5188040

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Abstract

Background: Homelessness might increase the risk of premature mortality, but evidence is scarce, imprecise, and is mostly limited to rough sleepers as opposed to more common types of homelessness. Methods: Published studies were retrieved through a systematic search of MEDLINE, Embase PsycINFO and Scopus from inception to December 2024. Unpublished data were identified from open-access data archives. We used random-effects meta-analysis to combine effect estimates from published and unpublished data. This review is registered at PROSPERO (CRD42023430984). Findings: We included 116 studies from Europe, the USA, South America, Africa, Asia, and Australia. The meta-analysis of all-cause mortality comprised 110,892,271 people (1,618,049 exposed to homelessness). The risk of all-cause mortality was significantly increased in people exposed to homelessness (Relative risk [RR] 2·12 [95% CI 1·91-2·57], p<0·001, I2=99·7%), with risks similar in men (3·88, 2·69-5·06) and women (3·46, 2·17-4·70). This risk was most elevated in people who had slept rough (7·63, 3·29-11·97), followed by those who used hostel accommodation (5·18, 1·14-9·23), then low-cost hotels (3·44, 2·10-4·77). In analyses of cause-specific mortality (26,291,900 people, 1,202,205 homeless), summary RR estimates were elevated for 33 of the 36 (92%) causes of death and highest for deaths due to psychoactive substance use disorder (21·36, 14·44-31·67), accidental injuries (13·15, 5·46-31·69), drug-overdose (10·80, 6·37-18·31), and those that are alcohol-related (5·93, 1·10-22·04). No evidence of publication bias was detected. Interpretation: Homeless people experience an increased risk of premature mortality across an array of health outcomes. That the most extreme inequities have an interrelated aetiology suggests a cross-sectoral medical, housing, and social care response is required. Funding The Centre for Homelessness Impact, Health and Care Research Wales, UK Medical Research Council (MR/P023444/1) and the US National Institute on Aging.

Item Type:	Website Content
Date Type:	Published Online
Status:	Submitted
Schools:	Schools > Social Sciences (Includes Criminology and Education) Schools > Medicine Research Institutes & Centres > Centre for Trials Research (CNTRR)
Publisher:	Elsevier
Last Modified:	11 Jul 2025 11:30
URI:	https://orca.cardiff.ac.uk/id/eprint/177594

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