Enhanced functionalities of biomaterials through metal ion surface modification

Tao, Yujie, Nishio Ayre, Wayne ORCID: https://orcid.org/0000-0003-2405-1876, Jiang, Liming, Chen, Siyu, Dong, Yuqi, Wu, Lin, Jiao, Yilai and Liu, Xiaohan 2025. Enhanced functionalities of biomaterials through metal ion surface modification. Frontiers in Bioengineering and Biotechnology 13 , 1522442. 10.3389/fbioe.2025.1522442

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Abstract

The development of new artificial biomaterials for bone defect repair is an ongoing area of clinical research. Metal ions such as zinc, copper, magnesium, calcium, strontium, silver, and cerium play various roles in bone tissue regeneration in the human body and possess a range of biochemical functions. Studies have demonstrated that appropriate concentrations of these metal ions can promote osteogenesis and angiogenesis, inhibit osteoclast activity, and deter bacterial infections. Researchers have incorporated metal ions into biomaterials using various methods to create artificial bone materials with enhanced osteogenic and antibacterial capabilities. In addition to the osteogenic properties of all the aforementioned metal ions, Zn, Sr, and Ce can indirectly promote osteogenesis by inhibiting osteoclast activity. Cu, Mg, and Sr significantly enhance angiogenesis, while the antibacterial properties of Zn, Cu, Ag, and Ce can reduce the likelihood of infection and inflammation caused by implanted materials. This paper reviews the mechanisms through which metal ions promote bone tissue growth and improve the antibacterial activity of biomaterials. It also summarizes common loading methods on the surface of biomaterials with different metals and highlights the potential clinical applications of these new artificial bone materials.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Schools > Dentistry
Publisher:	Frontiers Media
ISSN:	2296-4185
Date of First Compliant Deposit:	14 April 2025
Date of Acceptance:	1 April 2025
Last Modified:	15 Apr 2025 13:45
URI:	https://orca.cardiff.ac.uk/id/eprint/177626

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