Ji, Wenxiao, Zhuang, Xinguo, Jiang, Wen G.  ORCID: https://orcid.org/0000-0002-3283-1111 and Martin, Tracey A. ORCID: https://orcid.org/0000-0003-2690-4908
2025.
Tight junctional protein family, Claudins in cancer and cancer metastasis.
Frontiers in Oncology
15
, 1596460.
10.3389/fonc.2025.1596460
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Abstract
Claudin (CLDN) family proteins are key components of tight junctions in epithelial andendothelial cells, crucial for controlling paracellular permeability and cell-cell adhesion.Aberrant CLDNS expression is frequently observed in cancers and has been linked to tumorprogression, invasion, and metastasis [1] . Recent years have seen a rapid advance inexploring the role played by this protein family in cancer and cancer metastasis, and evenchemotherapy response. This article provides a comprehensive overview of the roles ofCLDNs in solid tumors, highlighting how specific CLDN members function as oncogenicdrivers or tumor suppressors in different cancer types. We also discuss the potential ofCLDNs as biomarkers for prognosis and therapeutic targets (e.g. CLDN18.2-targetedimmunotherapy) [1] . The inclusion of updated literature (particularly post-2020) andbioinformatic analyses (TCGA/GEPIA) reveal emerging trends. Finally, we summarizecommon patterns of CLDN dysregulation across cancers and outline future researchdirections, including pan-cancer CLDN analyses and translational strategies.
| Item Type: | Article |
|---|---|
| Date Type: | Publication |
| Status: | Published |
| Schools: | Schools > Medicine |
| Publisher: | Frontiers Media |
| Date of First Compliant Deposit: | 16 May 2025 |
| Date of Acceptance: | 13 May 2025 |
| Last Modified: | 23 Jul 2025 11:31 |
| URI: | https://orca.cardiff.ac.uk/id/eprint/178334 |
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