Frailty and stroke - global implications for assessment, research, and clinical care. A WSO scientific statement

Evans, Nicholas Richard, Pinho, João, Beishon, Lucy, Nguyen, Tu, Ganesh, Aravind, Balasundaram, Bharathi, Munthe-Kaas, Ragnhild, Hewitt, Jonathan ORCID: https://orcid.org/0000-0002-7924-1792, Gandhi, Dorcas Bc, Quinn, Terence Joseph and Lindley, Richard 2025. Frailty and stroke - global implications for assessment, research, and clinical care. A WSO scientific statement. International Journal of Stroke 10.1177/17474930251345295

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Abstract

Frailty is common in stroke and has important disease- and treatment-modifying effects. The need to develop clinical practice and research for the impact of frailty on stroke is likely to increase in the coming decades as the global population ages, resulting in a higher burden of frailty that is likely to be borne disproportionately by lower- and middle-income countries.The global nature of frailty in stroke necessitates global action. This World Stroke Organisation Scientific Statement synthesises the current evidence relating to the prevalence and effects of frailty across the stroke pathway. Furthermore, it includes expert consensus on priority areas from a global panel: standardisation of frailty assessments for research, explicit measurements of frailty (in addition to disability) in large clinical trials, dedicated studies investigating the treatment-modifying effects of frailty in acute stroke and secondary prevention, research investigating the impact of frailty on the different aspects of recovery and rehabilitation after stroke, and understanding the mechanisms underpinning the relationship between frailty and stroke for potential therapeutic exploitation.This scientific statement has been reviewed and approved by the World Stroke Organisation Executive.

Item Type:	Article
Date Type:	Published Online
Status:	In Press
Schools:	Schools > Medicine
Publisher:	SAGE Publications
ISSN:	1747-4930
Date of First Compliant Deposit:	18 September 2025
Last Modified:	18 Sep 2025 13:01
URI:	https://orca.cardiff.ac.uk/id/eprint/178754

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