Emerging therapies against Naegleria fowleri

Siddiqui, Ruqaiyyah, Lloyd, David ORCID: https://orcid.org/0000-0002-5656-0571, Alharbi, Ahmad M. and Khan, Naveed Ahmed 2025. Emerging therapies against Naegleria fowleri. Expert Opinion on Orphan Drugs 12 (1) , pp. 41-49. 10.1080/21678707.2024.2383173

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Abstract

Introduction Naegleria fowleri is a free-living protist pathogen. Given the opportunity, it can produce infection of the central nervous system. It is distressing that the brain-eating amoebae, Naegleria fowleri remains one of the lethal parasites resulting almost always in death, despite advances in antimicrobial chemotherapy and supportive care. Areas covered The overall aim is to present a timely review of our current understanding of emerging therapies and priorities. By searching bibliographic databases (PubMed) for the available peer-reviewed research literature, herein, we discuss current advances, challenges and opportunities pertinent in the development of therapeutic interventions. Expert opinion The prospect of exploring repurposed drugs in combination with nanotechnology and a theranostic approach to concurrently achieve diagnosis and drug delivery will offer promise in the rational development of effective therapies to counter N. folweri-associated fatal brain infections.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Schools > Biosciences
ISSN:	2167-8707
Date of First Compliant Deposit:	24 June 2025
Date of Acceptance:	12 July 2024
Last Modified:	24 Jun 2025 11:31
URI:	https://orca.cardiff.ac.uk/id/eprint/178801

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