Rapuc, Sara, Jary, Sally, Vanderwert, Ross E.  ORCID: https://orcid.org/0000-0002-2280-8401, Odd, David ORCID: https://orcid.org/0000-0002-6416-4966 and Chakkarapani, Ela
2025.
Cognitive development at late infancy and school age in children cooled for neonatal encephalopathy.
Pediatric Research
10.1038/s41390-025-04152-4
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Abstract
Background We investigated the association and individual changes in cognitive scores between late infancy and early school age in children cooled for neonatal encephalopathy secondary to perinatal asphyxia (NE) who did not develop cerebral palsy. Methods We included 50 children born ≥35 weeks gestation cooled for NE who did not develop cerebral palsy. We assessed cognition using an average of cognitive and language composite scores (CLC) from Bayley Scales of Infant and Toddler Development (Bayley-III) at 18–21 months and full-scale IQ (FSIQ) on Wechsler Intelligence Scale for Children (WISC-IV) at 6–8 years. Linear regression was used to assess the association between CLC and FSIQ. Results Our cohort’s mean gestation was 39.8 (SD 1.6) weeks; 59% male. 80% had moderate NE. CLC scores were significantly associated with FSIQ (Coef 0.45 (95% CI: 0.17, 0.72), R2 19%). About 45% of children’s cognitive scores lowered from 18 to 21 months to 6–8 years of age, with two FSIQ clusters differing by deprivation (7.3 vs 5.5, p = 0.009). Increasing CLC threshold to 95 still did not identify 63% having an FSIQ < 85. Conclusion Bayley-III underestimates the delay at school age in children cooled for NE. Childhood IQ after NE appeared to be patterned by local deprivation.
| Item Type: | Article |
|---|---|
| Date Type: | Published Online |
| Status: | In Press |
| Schools: | Schools > Medicine Schools > Psychology |
| Publisher: | Springer Nature [academic journals on nature.com] |
| ISSN: | 0031-3998 |
| Date of First Compliant Deposit: | 6 June 2025 |
| Date of Acceptance: | 12 May 2025 |
| Last Modified: | 17 Jun 2025 09:30 |
| URI: | https://orca.cardiff.ac.uk/id/eprint/178848 |
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