Spermatogenesis

Messer, Fiona ORCID: https://orcid.org/0000-0002-9377-750X, White-Cooper, Helen ORCID: https://orcid.org/0000-0002-3373-8023 and Amoyel, Marc 2025. Spermatogenesis. Reference Module in Life Sciences, Elsevier, (10.1016/B978-0-323-95424-2.00017-0)

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Abstract

Spermatogenesis is an extraordinarily complex cellular reorganization producing distinctive elongated haploid gametes. Successful spermatogenesis is critical to reproduction and species survival, and sperm, and the genes expressed in them, evolve rapidly. Across insects, sperm display a huge variety of forms. In this chapter, we explore current knowledge of insect spermatogenesis, with a primary focus on Drosophila melanogaster where genetic tools have provided insight into the molecular underpinning of the many cellular processes involved. We discuss the mechanisms by which germline stem cells and early germ cells (spermatogonia) interact with somatic cells to sustain lifelong spermatogenesis, then how spermatocytes acquire a unique transcriptome and undergo meiosis, eventually undergoing the characteristic morphogenetic events of spermiogenesis to produce mature sperm, and finally, we describe the diversity of sperm forms and mechanisms that produce such variety. New technologies will undoubtedly lead to profound new insights into this most important of cell transformations, with implications on understanding evolution and influencing fertility.

Item Type:	Book Section
Date Type:	Published Online
Status:	In Press
Schools:	Schools > Biosciences
Publisher:	Elsevier
ISBN:	9780128096338
Date of First Compliant Deposit:	9 June 2025
Date of Acceptance:	3 June 2025
Last Modified:	19 Jun 2025 14:30
URI:	https://orca.cardiff.ac.uk/id/eprint/178893

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