Direct medical cost of first-ever acute ischemic stroke in malaysia: a retrospective cohort study

Mohammed, Mustapha, Zainal, Hadzliana, Ong, Siew Chin, Tangiisuran, Balamurugan, Aziz, Fatimatuzzahra Abdul, Sha’aban, Abubakar ORCID: https://orcid.org/0000-0002-5491-9851, Abubakar, Usman, Sidek, Norsima Nazifah, Looi, Irene and Aziz, Zariah A. 2025. Direct medical cost of first-ever acute ischemic stroke in malaysia: a retrospective cohort study. Scientific Reports 15 (1) , 22571. 10.1038/s41598-025-07026-1

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Abstract

Understanding the economic impact of first-ever stroke in a multiethnic population like Malaysia is essential for informed resource allocation. This study aimed to evaluate the direct medical costs associated with first-ever ischemic stroke in Malaysia. The study was a retrospective cohort study that estimated the inpatient direct medical costs of first-ever ischemic stroke in Malaysia. The study involved 122 adult patients managed at Hospital Sultanah Nur Zahirah, Terengganu (HSNZ), enrolled in the Malaysian National Stroke Registry (NSR) from 2009 to 2020. The mean ± standard deviation (SD) for the patients’ age was 61.0 ± 10.9 years, the length of stay (LOS) was 4.5 ± 3.5 days, and the modified Rankin scale (mRS) score was 3.0 ± 1.1. Most patients experienced functional disability (poor functional status, mRS ≥ 3) and incurred an average (SD) treatment cost of MYR 1,970.7 ± 1,385.8, primarily attributed to hospital admissions and radiology expenses. The medical costs were significantly lower in patients with good functional status [mRS < 3 (p = 0.002)] and shorter LOS (p < 0.001), but higher in patients with the partial anterior circulation infarct (PACI) stroke subtype (p < 0.001). Additionally, patients with good functional status incurred significantly lower costs for admission and medications (p < 0.001). In conclusion, the inpatient direct medical cost of first-ever ischemic stroke in Malaysia is substantial and is influenced by stroke subtypes, length of stay, risk factors, and functional status. Strategies to reduce the length of stay, comorbidities, and functional status can potentially reduce the economic burden of the first-ever acute ischemic stroke. These findings are crucial for guiding the optimal allocation of resources for stroke care.

Item Type:	Article
Date Type:	Published Online
Status:	Published
Schools:	Schools > Medicine
Additional Information:	License information from Publisher: LICENSE 1: URL: http://creativecommons.org/licenses/by/4.0/, Type: open-access
Publisher:	Nature Research
ISSN:	2045-2322
Date of First Compliant Deposit:	7 July 2025
Date of Acceptance:	12 June 2025
Last Modified:	07 Jul 2025 15:15
URI:	https://orca.cardiff.ac.uk/id/eprint/179610

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