Da Silva, Igor F. P., Ducker, Charles, Pickett, John A.  ORCID: https://orcid.org/0000-0002-1008-6595, Santana, Antônio E. G. and Oldham, Neil J.
2025.
Stereoselective deprotonation installs an unusual Z -8,9 double bond during biosynthesis of the diterpene pheromone sobralene † ‡.
Chemical Communications
10.1039/d5cc03298a
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License URL: https://creativecommons.org/licenses/by/3.0/
License Start date: 7 July 2025
Official URL: https://doi.org/10.1039/d5cc03298a
Abstract
A terpene synthase from the sandfly Lutzomyia longipalpis, catalyses stereoselective removal of the pro-S proton from C8 of geranylgeranyl diphosphate to generate the characteristic (Z)-8,9 double bond seen in the diterpene pheromone sobralene. Retention of deuterium in structurally related minor products demonstrates that they are not produced via sobralene, but are made directly by the enzyme.
| Item Type: | Article |
|---|---|
| Date Type: | Published Online |
| Status: | In Press |
| Schools: | Schools > Chemistry |
| Additional Information: | License information from Publisher: LICENSE 1: URL: https://creativecommons.org/licenses/by/3.0/, Start Date: 2025-07-07 |
| Publisher: | Royal Society of Chemistry |
| ISSN: | 1359-7345 |
| Date of First Compliant Deposit: | 15 July 2025 |
| Date of Acceptance: | 1 July 2025 |
| Last Modified: | 15 Jul 2025 15:45 |
| URI: | https://orca.cardiff.ac.uk/id/eprint/179854 |
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