Sands, Kirsty, Lankapalli, Aditya Kumar, Lai, Giulia, Hassan, Brekhna, Portal, Edward A. R., Mathias, Jordan A. T., Boostrom, Ian, Li, Mei, Cook, Kate, Premchand-Branker, Shonnette, Jones, Lim S., Sayinzonga-Makombe, Nathan, Isanaka, Sheila, Kanapathipillai, Rupa, Mambula, Christopher, Mouniaman, Isabelle, Langendorf, Céline, Walsh, Timothy R. and Spiller, Owen B. ![]() ![]() |
![]() |
PDF
- Published Version
Available under License Creative Commons Attribution. Download (1MB) |
Abstract
Hospitalisation and routine antibiotic treatment are recommended for children with complicated severe acute malnutrition (SAM) but this may exacerbate antimicrobial resistance. Here, we investigate carriage of Gram-negative bacteria in children under five years of age receiving treatment for SAM in Niger, comparing the frequency of colonisation with bacteria carrying resistance genes at admission, during hospital stay and at discharge. E. coli isolates carrying a blaNDM-5 gene were selected for whole-genome sequencing. Rectal colonisation with bacteria carrying ß-lactamase genes is high, with 76% (n = 1042/1371) of children harbouring bacteria carrying a blaCTXM-1-group gene and 25% (n = 338/1371) carrying a blaNDM-5 gene. Over two-thirds of children who did not carry bacteria with a carbapenemase gene at admission are colonised with bacteria carrying a carbapenemase gene at discharge (n = 503/729, 69%). E. coli ST167 carrying blaNDM-5 gene is recovered from 11% (n = 144/1371) of children. Here we highlight infection control and bacterial AMR transmission concerns amongst a vulnerable population in need of medical treatment.
Item Type: | Article |
---|---|
Date Type: | Published Online |
Status: | Published |
Schools: | Schools > Medicine |
Additional Information: | License information from Publisher: LICENSE 1: URL: http://creativecommons.org/licenses/by/4.0/, Type: open-access |
Publisher: | Nature Research |
ISSN: | 2041-1723 |
Date of First Compliant Deposit: | 4 August 2025 |
Date of Acceptance: | 27 June 2025 |
Last Modified: | 04 Aug 2025 14:15 |
URI: | https://orca.cardiff.ac.uk/id/eprint/180251 |
Actions (repository staff only)
![]() |
Edit Item |