Multi-centre investigation of cardiac diffusion tensor imaging in healthy volunteers by SCMR cardiac diffusion special interest group NETwork (SIGNET)

Teh, Irvin, Moulin, Kévin, Ferreira, Pedro F., Absil, Julie, Afzali, Maryam, Agger, Peter, Akbari, Behnaz, Aletras, Anthony H., Aono, Satoru, Benton, Charles, Bhattacharya, Suryava, Croisille, Pierre, De Bruecker, Yves, Dall’Armellina, Erica, Ennis, Daniel B., Glessgen, Carl, Glinska, Anna, Haltmeier, Sandra, Hannum, Ariel, Hedström, Erik, Hussein, Tawfik, Jones, Sarah, Joy, George, Kettless, Karen, Kim, Won Yong, Kozerke, Sebastian, Magat, Julie, Muthupillai, Raja, Nezafat, Reza, Nielles-Vallespin, Sonia, Oshinski, John, Ozenne, Valéry, Pennell, Dudley J., Pettigrew, Roderick, Pierce, Iain, Raman, Betty, Sabisz, Agnieszka, Schneider, Jürgen E., Sherman, Janet H., Shetye, Abhishek, Symons, Rolf, Thoma, Philippe, Treibel, Thomas, Tsuneta, Satonori, Vallee, Jean-Paul, Vejlstrup, Niels, Viallon, Magalie, Nguyen, Christopher, Scott, Andrew D. and Stoeck, Christian T. 2025. Multi-centre investigation of cardiac diffusion tensor imaging in healthy volunteers by SCMR cardiac diffusion special interest group NETwork (SIGNET). Journal of Cardiovascular Magnetic Resonance , 101948. 10.1016/j.jocmr.2025.101948

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Abstract

Background: Cardiac diffusion tensor imaging (cDTI) is an emerging technique for microstructural characterization of the heart and has shown clinical potential in a range of cardiomyopathies. However, there is substantial variation reported for in vivo cDTI results across the literature, and sensitivity of cDTI to differences in imaging sites, scanners, acquisition protocols and post-processing methods remains incompletely understood. Methods: SIGNET is a prospective multi-centre, observational study in travelling and non-travelling healthy volunteers. The study was initiated by the executive board of the SCMR Cardiac Diffusion Special Interest Group (SIG) as a follow up to a previous multi-centre study on phantom validation of cardiac DTI and a recently published SCMR consensus statement on cardiac diffusion MRI. The study has been developed by the Project Management Committee in consultation with the SCMR Cardiac Diffusion SIG, which includes international experts in cardiac diffusion MRI. To date, more than 20 international institutions have engaged with the study, including sites that are new to cardiac DTI, making this the largest collaborative effort in the field. Discussion: SIGNET will provide important information about the key sources of variation in cardiac DTI. This will help rationalise strategies for addressing and minimising such variation. Harmonisation of protocols in this and future studies will underpin efforts to translate cardiac DTI for clinical application.

Item Type:	Article
Date Type:	Published Online
Status:	In Press
Schools:	Schools > Psychology Research Institutes & Centres > Cardiff University Brain Research Imaging Centre (CUBRIC)
Additional Information:	License information from Publisher: LICENSE 1: URL: http://creativecommons.org/licenses/by/4.0/, Start Date: 2025-08-20
Publisher:	Elsevier
ISSN:	1097-6647
Date of First Compliant Deposit:	2 September 2025
Date of Acceptance:	19 August 2025
Last Modified:	02 Sep 2025 11:00
URI:	https://orca.cardiff.ac.uk/id/eprint/180829

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