Origin and maintenance of the intestinal cancer stem cell

Davies, Emma Jane, Marsh Durban, Victoria ORCID: https://orcid.org/0000-0003-1645-1618 and Clarke, Alan Richard ORCID: https://orcid.org/0000-0002-4281-426X 2011. Origin and maintenance of the intestinal cancer stem cell. Molecular Carcinogenesis 50 (4) , pp. 254-263. 10.1002/mc.20631

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Abstract

Colorectal cancer is one of the most common cancers in the western world and its incidence is steadily increasing. Understanding the basic biology of both the normal intestine and of intestinal tumorigenesis is vital for developing appropriate and effective cancer therapies. However, relatively little is known about the normal intestinal stem cell or the hypothetical intestinal cancer stem cell, and there is much debate surrounding these areas. This review briefly describes our current understanding of the properties of both the intestinal stem cell and the intestinal cancer stem cell. We also discuss recent theories regarding the origin of the intestinal cancer stem cell, and the signals required for its maintenance and proliferation. Finally, we place the relevance of cancer stem cell research into context by discussing potential clinical applications of targeting the intestinal cancer stem cell.

Item Type:	Article
Status:	Published
Schools:	Biosciences European Cancer Stem Cell Research Institute (ECSCRI)
Subjects:	R Medicine > R Medicine (General) R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)
Uncontrolled Keywords:	cancer stem cells; intestine; Wnt pathway
Additional Information:	Special issue: Exploring cancer-related genes: Application for molecular target-based therapy and prevention. Article first published online: 4 APR 2011
Publisher:	Wiley-Blackwell
ISSN:	0899-1987
Related URLs:	http://www.ncbi.nlm.nih.gov/pubmed/21465... http://www.apcfindit.com/cachedxml?hl=no...
Last Modified:	19 Oct 2022 08:33
URI:	https://orca.cardiff.ac.uk/id/eprint/18216

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