DNA‐binding properties of iridium(III) complexes encompassing design, function and biophysical assessments

Alkhaibari, Ibrahim S., Buurma, Niklaas J. ORCID: https://orcid.org/0000-0003-0260-5057 and Pope, Simon J. A. ORCID: https://orcid.org/0000-0001-9110-9711 2026. DNA‐binding properties of iridium(III) complexes encompassing design, function and biophysical assessments. ChemPhysChem 27 (11) , e70426. 10.1002/cphc.70426

PDF - Published Version Available under License Creative Commons Attribution. Download (3MB)

Abstract

The increasingly diverse biological applications of iridium(III) complexes, from luminescent cellular imaging agents to therapeutic and prospective theranostics, has been enabled by a combination of imaginative ligand design and tunable (photo)physical properties. Within this biological context, it is crucial to understand how molecular probes interact with biological substrates and macromolecules. This review focuses upon the structural diversity of DNA‐binding metal complexes based upon iridium(III), the general workflow used to interrogate these interactions with DNA, and critically analyses the relationship between complex structure and functionality.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Schools > Chemistry
Additional Information:	License information from Publisher: LICENSE 1: URL: http://creativecommons.org/licenses/by/4.0/
Publisher:	Wiley
ISSN:	1439-4235
Date of First Compliant Deposit:	10 June 2026
Date of Acceptance:	7 May 2026
Last Modified:	25 Aug 2026 22:05
URI:	https://orca.cardiff.ac.uk/id/eprint/187496

Actions (repository staff only)

Edit Item