Immunohistochemical analysis of oligodendrocyte lineage cells and myelin in murine central nervous system

Wang, Tianqi and Syed, Yasir Ahmed ORCID: https://orcid.org/0000-0001-9495-307X 2026. Immunohistochemical analysis of oligodendrocyte lineage cells and myelin in murine central nervous system. Herbst, Ebru Ercan, ed. Oligodendrocytes, Methods in Molecular Biology, No. 3098. New York: Humana Press, pp. 185-194. (10.1007/978-1-0716-5671-6_12)

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Abstract

White matter, composed of axons ensheathed in myelin produced by mature oligodendrocytes, is essential for the rapid and efficient transmission of electrical impulses throughout the nervous system. The development of oligodendrocytes follows a tightly regulated lineage progression, beginning with neural progenitor cells (NPCs) that differentiate into oligodendrocyte progenitor cells (OPCs). These OPCs undergo proliferation, migration, and ultimately terminal differentiation into mature, myelinating oligodendrocytes. Disruptions at any stage of this developmental cascade—whether in lineage specification, proliferation, migration, or maturation—can impair myelination and contribute to the pathophysiology of neurodevelopmental disorders (NDDs). Therefore, identifying the precise stage at which oligodendrocyte lineage progression is altered is critical for elucidating the cellular and molecular mechanisms underlying NDDs.

Item Type:	Book Section
Date Type:	Publication
Status:	Published
Schools:	Schools > Biosciences
Publisher:	Humana Press
ISBN:	9781071656709
ISSN:	1064-3745
Last Modified:	02 Nov 2026 15:09
URI:	https://orca.cardiff.ac.uk/id/eprint/190600

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