Identification of plasmepsin inhibitors as selective anti-malarial agents using ligand based drug design

McKay, Paul, Peters, Martin, Carta, Giorgio, Flood, Christopher, Dempsey, Enda, Bell, Angus, Berry, Colin ORCID: https://orcid.org/0000-0002-9943-548X, Lloyd, David ORCID: https://orcid.org/0000-0002-5656-0571 and Fayne, Darren 2011. Identification of plasmepsin inhibitors as selective anti-malarial agents using ligand based drug design. Bioorganic & Medicinal Chemistry Letters 21 (11) , pp. 3335-3341. 10.1016/j.bmcl.2011.04.015

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Abstract

We describe the application of ligand based virtual screening technologies towards the discovery of novel plasmepsin (PM) inhibitors, a family of malarial parasitic aspartyl proteases. Pharmacophore queries were used to screen vendor libraries in search of active and selective compounds. The virtual hits were biologically assessed for activity and selectivity using whole cell Plasmodium falciparum parasites and on target in PM II, PM IV and the closely related human homologue, Cathepsin D assays. Here we report the virtual screening highlights, structures of the hits and their demonstrated biological activity.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Biosciences
Subjects:	Q Science > Q Science (General)
Uncontrolled Keywords:	ligand based drug design; catalyst; plasmepsin inhibitors; Malaria; aspartyl proteases inhibitor
Publisher:	Elsevier
ISSN:	0960-894X
Last Modified:	19 Oct 2022 08:53
URI:	https://orca.cardiff.ac.uk/id/eprint/19386

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