Lymphangiogenesis and cancer metastasis

Al-Rawi, A. A. Mahir and Jiang, Wen Guo ORCID: https://orcid.org/0000-0002-3283-1111 2011. Lymphangiogenesis and cancer metastasis. Frontiers in Bioscience 16 (1) , pp. 723-739. 10.2741/3715

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Abstract

Lymphangiogenesis remains a fascinating biological process that plays a crucial role in both normal tissue development and several lymphatic diseases. The last few years have witnessed a rapid progression in understanding the development and regulation of the lymphatic system which provided insight on several pathological processes including cancer lymphatic metastasis. Lymphatic vasculature serves as a major route for tumour metastasis. The dissemination of malignant cells to the regional lymph nodes is an early step in the progression of many solid tumours and is an important determinant of staging and prognosis. Lymphangiogenesis is thought to play a pivotal role for cancer cells to metastasise to the regional lymph nodes. Several human solid tumours are now considered to be lymphangiogenic i.e. they have the ability to induce their own lymphatic vessels to establish metastasis. Hence, targeting lymphangiogenesis by developing anti-lymphangiogenic agents might constitute a novel way to prevent lymphatic progression in some tumours. Here, we have reviewed the development of the lymphatic system, the regulation of lymphangiogenesis and explored its relation to several human cancers.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine
Subjects:	R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)
Publisher:	Frontiers in Bioscence
ISSN:	1093-9946
Last Modified:	19 Oct 2022 08:54
URI:	https://orca.cardiff.ac.uk/id/eprint/19438

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