Angotti, M., Hartmann, R. W,, Kirby, Andrew James, Simons, Claire ![]() |
Abstract
The effect of the titled tetralone as a retinoic acid metabolism blocking agent (RAMBA) in vivo in comparison with ketoconazole, a well known cytochrome P450 inhibitor, was studied. Development of a HPLC/MS/MS method for the quantification of retinoic acid levels extracted from rat plasma was used to demonstrate that ketoconazole and the tetralone (100 mg/kg) enhanced the endogenous plasma concentration of retinoic acid. Levels of retinoid were raised from a control value of 0.11 to 0.15 and 0.17 ng/mL after treatment with tetralone and ketoconazole respectively showing that the tetralone and ketoconazole lead to comparable effects, indicating an inhibitory activity of the tetralone on retinoic acid metabolism.
Item Type: | Article |
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Date Type: | Submission |
Status: | Published |
Schools: | Pharmacy |
Subjects: | R Medicine > RS Pharmacy and materia medica |
Related URLs: | |
Last Modified: | 19 Oct 2022 09:03 |
URI: | https://orca.cardiff.ac.uk/id/eprint/19832 |
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