Hepatocyte growth factor signalling in cancer metastasis

Martin, Tracey Amanda ORCID: https://orcid.org/0000-0003-2690-4908, Mason, Malcolm David ORCID: https://orcid.org/0000-0003-1505-2869 and Jiang, Wen Guo ORCID: https://orcid.org/0000-0002-3283-1111 2011. Hepatocyte growth factor signalling in cancer metastasis. Current Signal Transduction Therapy 6 (2) , pp. 180-190. 10.2174/157436211795659991

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Abstract

Since their discovery in the late 1980's, Hepatocyte growth factor (HGF) and it's receptor, c-MET, have become the focus of intense scrutiny as regards their role in cancer and metastasis [1, 2]. HGF is now known to be a potent morphogen that can regulate tissue and organ regeneration and modulate cell morphology, it is a motogen that can stimulate cell motility and migration, and is a mitogen able to regulate cell growth and death and is a powerful angiogenic and lymphangiogenic factor [3-5]. The diverse range of functions that can be ascribed to HGF/c-MET is transmitted via a variety of cell signaling pathways. This review will focus on recent work demonstrating the importance of HGF/c-MET in regulating these signaling events, how they are related to cancer metastasis and where they may be targeted for patient intervention.

Item Type:	Article
Status:	Published
Schools:	Schools > Medicine
Subjects:	R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)
Uncontrolled Keywords:	Cancer; HGF; Metastasis; Signaling; HGF; c-MET; intracellular signalling; Grb2/SOS; Gab1; PI3 kinase; Stat3; Wnt signaling; Rho/Rac; Protein Kinase C; protein tyrosine phosphates; MAPK; mTOR; ERK; Mcl-1; RAS; MEK; LKB1; Cdc42; Mig6; Phospholipase C g-; cRaf; Catenin; Paxillin; FAK
Publisher:	Bentham Science Publishers
ISSN:	1574-3624
Last Modified:	19 Oct 2022 09:06
URI:	https://orca.cardiff.ac.uk/id/eprint/20026

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