Cardiff University | Prifysgol Caerdydd ORCA
Online Research @ Cardiff 
WelshClear Cookie - decide language by browser settings

Characterization of age-related variation in corneal biomechanical properties

Elsheikh, Ahmed, Geraghty, Brendan, Rama, Paolo, Campanelli, Marino and Meek, Keith Michael Andrew ORCID: https://orcid.org/0000-0002-9948-7538 2010. Characterization of age-related variation in corneal biomechanical properties. Journal of The Royal Society Interface 7 (51) , pp. 1475-1485. 10.1098/rsif.2010.0108

Full text not available from this repository.

Abstract

An experimental study has been conducted to determine the stress–strain behaviour of human corneal tissue and how the behaviour varies with age. Fifty-seven well-preserved ex vivo donor corneas aged between 30 and 99 years were subjected to cycles of posterior pressure up to 60 mm Hg while monitoring their behaviour. The corneas were mechanically clamped along their ring of scleral tissue and kept in physiological conditions of temperature and hydration. The tissue demonstrated hyper-elastic pressure-deformation and stress–strain behaviour that closely matched an exponential trend. Clear stiffening (increased resistance to deformation) with age was observed in all loading cycles, and the rate of stiffness growth was nonlinear with bias towards older specimens. With a strong statistical association between stiffness and age (p < 0.05), it was possible to develop generic stress–strain equations that were suitable for all ages between 30 and 99 years. These equations, which closely matched the experimental results, depicted corneal stiffening with age in a form suitable for implementation in numerical simulations of ocular biomechanical behaviour.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Optometry and Vision Sciences
Subjects: R Medicine > RE Ophthalmology
Uncontrolled Keywords: ocular biomechanics; cornea; ageing; stress–strain behaviour
Publisher: The Royal Society
ISSN: 1742-5689
Last Modified: 19 Oct 2022 09:45
URI: https://orca.cardiff.ac.uk/id/eprint/22096

Citation Data

Cited 127 times in Scopus. View in Scopus. Powered By Scopus® Data

Actions (repository staff only)

Edit Item Edit Item