NRG1gene in recurrent major depression: No association in a large-scale case-control association study

Schosser, A., Cohen-Woods, S., Gaysina, D., Chow, P. C., Martucci, L., Farmer, A., Korszun, A., Gunashinghe, C., Gray, J., Jones, L., Craddock, Nicholas John ORCID: https://orcid.org/0000-0003-2171-0610, Owen, Michael John ORCID: https://orcid.org/0000-0003-4798-0862, Craig, I. W. and McGuffin, P. 2009. NRG1gene in recurrent major depression: No association in a large-scale case-control association study. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 153B (1) , pp. 141-147. 10.1002/ajmg.b.30965

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Abstract

The Neuregulin 1 (NRG1) gene was initially implicated in schizophrenia (SZ) and has recently been associated with bipolar disorder (BPD) in two studies. An association with major depressive disorder (MDD) has not yet been investigated but is warranted in view of the genetic overlap between MDD and BPD. We have performed a large-scale case–control study investigating the association between NRG1 polymorphisms and MDD, genotyping a selection of 14 single nucleotide polymorphisms (SNPs) spanning the NRG1 gene in a sample of 1,398 patients of White European ancestry with a diagnosis of MDD and 1,304 ethnically matched controls from three clinical sites in the UK. We found no single marker or haplotype associations that withstood correction for multiple testing. Our findings do not provide evidence that NRG1 plays a role in MDD or that this gene explains part of the genetic overlap with BPD.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG) Neuroscience and Mental Health Research Institute (NMHRI)
Subjects:	Q Science > QH Natural history > QH426 Genetics R Medicine > R Medicine (General) R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Uncontrolled Keywords:	NRG1; depression; association; affective disorders
Publisher:	Wiley-Blackwell
ISSN:	1552-4841
Last Modified:	19 Oct 2022 09:46
URI:	https://orca.cardiff.ac.uk/id/eprint/22126

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