Effect of a proparacaine 0.50%-sodium fluorescein 0.25% mix and contact ultrasound pachymetry on central and midperipheral corneal thickness measured by noncontact optical pachymetry

Mukhopadhyay, Ditipriya R., North, Rachel Valerie ORCID: https://orcid.org/0000-0002-6657-5099 and Hamilton-Maxwell, Kirsten ORCID: https://orcid.org/0000-0002-4412-3278 2011. Effect of a proparacaine 0.50%-sodium fluorescein 0.25% mix and contact ultrasound pachymetry on central and midperipheral corneal thickness measured by noncontact optical pachymetry. Journal of Cataract & Refractive Surgery 37 (5) , pp. 907-913. 10.1016/j.jcrs.2010.11.033

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Abstract

Purpose To assess the effect of a combination of proparacaine 0.50%–sodium fluorescein 0.25% and ultrasound (US) pachymetry on central and midperipheral corneal thickness. Setting School of Optometry and Vision Sciences, Cardiff University, Cardiff, Wales, United Kingdom. Design Case series. Method Topographic measurements of corneal thickness in healthy right eyes were obtained using a scanning-slit device (Orbscan IIz) and a Scheimpflug device (Pentacam) before and after application of proparacaine 0.50%–sodium fluorescein 0.25% and US pachymetry. Changes in corneal thickness in the center and 2.5 mm from the center in the temporal, nasal, inferior, and superior locations were assessed. Results The study evaluated 35 eyes. The scanning-slit and Scheimpflug devices recorded a small but statistically significant increase in corneal thickness at all locations (mean 4.9 ± 14.3 [SD] to 9.1 ± 11.7 μm; P<.05, paired t test). The cornea swelled uniformly across its diameter (scanning slit, P=.934; Scheimpflug, P=.654; analysis of variance); there was no statistically significant difference in the amount of swelling between the 2 devices (P>.05, t test). The 95% limits of agreement were broad (−10 to +30 μm), suggesting a large degree of interindividual variability. Conclusions Ultrasound pachymetry combined with proparacaine 0.50%–sodium fluorescein 0.25% caused a small (<10 μm) but significant amount of corneal swelling on average. Because the effect on corneal thickness may be greater than −10 to +30 μm in individual cases, clinicians should avoid contact procedures before obtaining topographic maps of corneal thickness using scanning-slit and Scheimpflug devices.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Optometry and Vision Sciences
Subjects:	R Medicine > RE Ophthalmology
Additional Information:	Presented in part at the annual meeting of the Association for Research in Vision and Ophthalmology, Fort Lauderdale, Florida, USA, May 2009, and the annual conference of the European Academy of Optometry and Optics, Lausanne, Switzerland, May 2009.
Publisher:	Elsevier
ISSN:	0886-3350
Last Modified:	05 Nov 2022 15:08
URI:	https://orca.cardiff.ac.uk/id/eprint/22454

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