Edden, Richard Anthony Edward, Harris, Ashley D., Murphy, Kevin  ORCID: https://orcid.org/0000-0002-6516-313X, Evans, Christopher John ORCID: https://orcid.org/0000-0002-6619-4245, Saxena, Neeraj ORCID: https://orcid.org/0000-0003-0913-9351, Hall, Judith Elizabeth ORCID: https://orcid.org/0000-0002-6770-7372, Bailey, Damian M. and Wise, Richard Geoffrey ORCID: https://orcid.org/0000-0003-1700-2144
2010.
Edited MRS is sensitive to changes in lactate concentration during inspiratory hypoxia.
Journal of Magnetic Resonance Imaging
32
(2)
, pp. 320-325.
10.1002/jmri.22233
|
Abstract
Purpose: To demonstrate the application of Mescher-Garwood (MEGA) point-resolved spectroscopy sequence (PRESS) editing to the detection of lactate in the brain at 3T and to investigate changes in lactate concentration associated with inspiratory gas challenges. Materials and Methods: Edited lactate measurements were made in six healthy volunteers while the subjects breathed normoxic (21% O2), hypoxic (12% O2), and hyperoxic (40% O2) gas mixtures. Lactate concentration was quantified relative to the unsuppressed water signal from the same volume. Results: Lactate concentration was elevated in all subjects during hypoxia in a highly significant fashion (mean increase = 39%; P = 0.0003). There was no significant change seen in hyperoxia. Conclusion: MEGA-PRESS editing at 3T is sufficiently sensitive to detect lactate in the healthy brain with good signal-to-noise ratio (SNR), and can be used to investigate changes in cerebral metabolism arising during inspiratory gas challenges.
| Item Type: | Article |
|---|---|
| Date Type: | Publication |
| Status: | Published |
| Schools: | Research Institutes & Centres > Cardiff University Brain Research Imaging Centre (CUBRIC) Schools > Medicine Schools > Psychology Research Institutes & Centres > Neuroscience and Mental Health Research Institute (NMHII) Schools > Physics and Astronomy |
| Subjects: | R Medicine > R Medicine (General) |
| Uncontrolled Keywords: | MRS ; Lactate ; Hypoxia ; Hyperoxia ; MEGA-PRESS |
| Publisher: | John Wiley & Sons |
| ISSN: | 1053-1807 |
| Last Modified: | 23 May 2024 01:06 |
| URI: | https://orca.cardiff.ac.uk/id/eprint/22885 |
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