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Edited MRS is sensitive to changes in lactate concentration during inspiratory hypoxia

Edden, Richard Anthony Edward, Harris, Ashley D., Murphy, Kevin, Evans, Christopher John, Saxena, Neeraj, Hall, Judith Elizabeth, Bailey, Damian M. and Wise, Richard Geoffrey 2010. Edited MRS is sensitive to changes in lactate concentration during inspiratory hypoxia. Journal of Magnetic Resonance Imaging 32 (2) , pp. 320-325. 10.1002/jmri.22233

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Purpose: To demonstrate the application of Mescher-Garwood (MEGA) point-resolved spectroscopy sequence (PRESS) editing to the detection of lactate in the brain at 3T and to investigate changes in lactate concentration associated with inspiratory gas challenges. Materials and Methods: Edited lactate measurements were made in six healthy volunteers while the subjects breathed normoxic (21% O2), hypoxic (12% O2), and hyperoxic (40% O2) gas mixtures. Lactate concentration was quantified relative to the unsuppressed water signal from the same volume. Results: Lactate concentration was elevated in all subjects during hypoxia in a highly significant fashion (mean increase = 39%; P = 0.0003). There was no significant change seen in hyperoxia. Conclusion: MEGA-PRESS editing at 3T is sufficiently sensitive to detect lactate in the healthy brain with good signal-to-noise ratio (SNR), and can be used to investigate changes in cerebral metabolism arising during inspiratory gas challenges.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Cardiff University Brain Research Imaging Centre (CUBRIC)
Neuroscience and Mental Health Research Institute (NMHRI)
Physics and Astronomy
Subjects: R Medicine > R Medicine (General)
Uncontrolled Keywords: MRS ; Lactate ; Hypoxia ; Hyperoxia ; MEGA-PRESS
Publisher: John Wiley & Sons
ISSN: 1053-1807
Last Modified: 08 May 2019 14:04

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