GalR2/3 mediates proliferative and trophic effects of galanin on postnatal hippocampal precursors

Abbosh, Christopher, Lawkowski, Alexandra, Zaben, Malik J. A. ORCID: https://orcid.org/0000-0002-7446-4532 and Gray, William Peter ORCID: https://orcid.org/0000-0001-7595-8887 2011. GalR2/3 mediates proliferative and trophic effects of galanin on postnatal hippocampal precursors. Journal of Neurochemistry 117 (3) , pp. 425-436. 10.1111/j.1471-4159.2011.07204.x

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Abstract

Understanding how neural activity is functionally linked to the stem cell niche, is assuming ever increasing importance as hippocampal neurogenesis is shown to be important for modulating the behavioural responses to stress and for certain forms of learning and memory. Neuropeptides such as neuropeptide Y and vasoactive intestinal peptide have emerged as important mediators for signalling local interneuron activity to subgranular zone precursors, however, little is known regarding the effects of neuropeptides that are extrinsic modulators of hippocampal information processing. Here, we show that the galanin GalR2/3 agonist Gal2–11 is both trophic and proliferative for postnatal subgranular precursors and proliferating neuroblasts at 10 nM and is purely trophic at doses as low as 100 pM. We found no effect mediated via GalR1. As galanin is co-released from noradrenergic and serotonergic projection neurons to the dentate gyrus, these findings support a direct effect of galanin on hippocampal neurogenesis, which may partly mediate its antidepressant effect via GalR2/3 receptors.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Biosciences MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG) Medicine Neuroscience and Mental Health Research Institute (NMHRI)
Subjects:	Q Science > Q Science (General) R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Uncontrolled Keywords:	dentate gyrus; galanin; galanin receptor-2/3; neurogenesis; Prox-1
Publisher:	Wiley
ISSN:	0022-3042
Last Modified:	14 Sep 2024 01:32
URI:	https://orca.cardiff.ac.uk/id/eprint/23166

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