The vital osteoclast: how is it regulated? [Editorial]

Aeschlimann, Daniel ORCID: https://orcid.org/0000-0003-0930-7706 and Evans, Bronwen Alice James ORCID: https://orcid.org/0000-0002-3082-1008 2004. The vital osteoclast: how is it regulated? [Editorial]. Cell Death and Differentiation 11 (S) , S5-S7. 10.1038/sj.cdd.4401470

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Abstract

Bone is a rigid but dynamic organ. Once formed, it is continually broken down and reformed by the co-ordinated actions of osteoclasts (that mediate resorption) and osteoblasts (that mediate formation) on trabecular bone surfaces and in the Haversian systems of cortical bone. Any net change in bone mass therefore reflects a change in the balance between these two processes. If osteoclastic bone resorption exceeds the bone-forming capacity of osteoblasts, the result is osteoporosis, but if the opposite occurs the result is osteopetrosis. This remodelling occurs in focal and discrete packets – bone-remodelling units – throughout the skeleton. As the remodelling that occurs in each unit is geographically and chronologically separated from other units of remodelling, it is thought that activation of the sequence of cellular events responsible is locally controlled, probably by paracrine signalling in the bone microenvironment.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Dentistry Medicine
Subjects:	Q Science > Q Science (General)
Publisher:	Nature Publishing Group
ISSN:	1350-9047
Last Modified:	19 Oct 2022 10:18
URI:	https://orca.cardiff.ac.uk/id/eprint/23903

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