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Lid wiper epitheliopathy, ocular surface and tear film in symptomatic contact lens wearers [Abstract Only]

Pult, Heiko, Purslow, Christine, Murphy, Paul James and Berry, Monica 2008. Lid wiper epitheliopathy, ocular surface and tear film in symptomatic contact lens wearers [Abstract Only]. Acta Ophthalmologica -New Series- 86 (s243) 10.1111/j.1755-3768.2008.4334.x

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Abstract

Purpose Lid wiper epitheliopathy (LWE) as well as lid parallel conjunctival folds (LIPCOF) are related to dry eye symptoms in contact lens weares and are thought to be caused by mechanical forces during blinking. This study investigates whether any correlations are detectable between LWE and LIPCOF and the ocular surface and tear film in soft contact lens wearers. Methods 38 subjects were classified asymptomatic and 23 symptomatic by the Contact Lens Dry Eye Questionnaire. Pre-lens break-up time, ocular hyperaemia, corneal staining, LWE and LIPCOF were assessed in the right eyes of 61 (23 males, 38 females; mean age = 32.1 ±11.4yrs) experienced lens wearers. Pre-ocular fluid was sampled using Schirmer strips pressed onto the temporal conjunctiva, and from harvested contact lenses. Mucins were assessed in dot-blots and in Western blots after electrophoresis on 1% agarose or 4-12% NuPAGE Gels. Results LWE and LIPCOF were significantly increased in the symptomatic group (p<0.03). Significant correlations were found between LWE and both temporal LIPCOF (r=0.67, p<0.001), and nasal LIPCOF (r=0.39, p<0.001), and between LWE and bulbar hyperaemia (r=0.28, p<0.001). MUC5AC reactivity was significantly decreased in symptomatics (p=0.050). MUC4 was negatively correlated to temporal LIPCOF and LWE (r=-0.47 and -0.46; p<0.01), MUC16 and MUC5AC correlated with corneal staining (0.36<r<0.53;p<0.04) Conclusion Symptomatic contact lens wearers exhibit significantly more LWE and LIPCOF, and decreased MUC5AC reactivity. Decreased mucins are associated with LWE and LIPCOF severity. Correlations between LWE and LIPCOF may reflect their common frictional origin. Increased friction might follow from insufficient mucins at the ocular surface.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Optometry and Vision Sciences
Subjects: R Medicine > RE Ophthalmology
Additional Information: Special Issue: Abstracts from the 2008 European Association for Vision and Eye Research Conference
Publisher: Wiley-Blackwell
ISSN: 1755-375X
Last Modified: 04 Jun 2017 03:38
URI: http://orca.cardiff.ac.uk/id/eprint/23943

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