A coupled drug kinetics-cell cycle model to analyse the response of human cells to intervention by topotecan

Chappell, Michael J., Evans, N. D., Errington, Rachel Jane ORCID: https://orcid.org/0000-0002-8016-4376, Khan, Imtiaz Ali, Campbell, Lee, Ali, R., Godfrey, K. R. and Smith, Paul James 2008. A coupled drug kinetics-cell cycle model to analyse the response of human cells to intervention by topotecan. Computer Methods and Programs in Biomedicine 89 (2) , pp. 169-178. 10.1016/j.cmpb.2007.11.002

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Abstract

A model describing the response of the growth of single human cells in the absence and presence of the anti-cancer agent topotecan (TPT) is presented. The model includes a novel coupling of both the kinetics of TPT and cell cycle responses to the agent. By linking the models in this way, rather than using separate (disjoint) approaches, it is possible to illustrate how the drug perturbs the cell cycle. The model is compared to experimental in vitro cell cycle response data (comprising single cell descriptors for molecular and behavioural events), showing good qualitative agreement for a range of TPT dose levels.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine Neuroscience and Mental Health Research Institute (NMHRI)
Subjects:	Q Science > QA Mathematics > QA75 Electronic computers. Computer science R Medicine > R Medicine (General)
Uncontrolled Keywords:	Drugkinetics; Cellcyclemodels; Compartmental models; Topotecan
Publisher:	Elsevier
ISSN:	0169-2607
Last Modified:	19 Oct 2022 10:26
URI:	https://orca.cardiff.ac.uk/id/eprint/24353

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