FKBP12.6 binding of ryanodine receptors carrying mutations associated with arrhythmogenic cardiac disease

Zissimopoulos, Spryos, Thomas, Nia Lowri ORCID: https://orcid.org/0000-0001-8822-8576, Jamaluddin, Wan W. and Lai, Francis Anthony ORCID: https://orcid.org/0000-0003-2852-8547 2009. FKBP12.6 binding of ryanodine receptors carrying mutations associated with arrhythmogenic cardiac disease. Biochemical Journal 419 (2) , pp. 273-278. 10.1042/BJ20082324

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Abstract

In the present paper we show that distinct human RyR2 (ryanodine receptor type 2) inherited mutations expressed in mammalian cells exhibit either unaltered or increased FKBP12.6 (12.6 kDa FK506-binding protein) binding compared with the wild-type. Oxidizing conditions result in decreased FKBP12.6 binding, but to the same extent as for the wild-type. Our findings suggest that FKBP12.6 regulation of RyR2 is unlikely to be the primary defect in inherited arrhythmogenic cardiac disease.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine
Subjects:	R Medicine > RG Gynecology and obstetrics
Uncontrolled Keywords:	arrhythmogenic cardiac disease; FKBP12.6; immunophilin, protein interaction; redox regulation; ryanodine receptor
Publisher:	Biochemical Society
ISSN:	0264-6021
Last Modified:	19 Oct 2022 10:39
URI:	https://orca.cardiff.ac.uk/id/eprint/25130

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