Schizophrenia genetics: advancing on two fronts

Owen, Michael John ORCID: https://orcid.org/0000-0003-4798-0862, Williams, Hywel John ORCID: https://orcid.org/0000-0001-7758-0312 and O'Donovan, Michael Conlon ORCID: https://orcid.org/0000-0001-7073-2379 2009. Schizophrenia genetics: advancing on two fronts. Current Opinion in Genetics & Development 19 (3) , pp. 266-270. 10.1016/j.gde.2009.02.008

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Abstract

Recent studies have supported the hypothesis that the high heritability of schizophrenia reflects a combination of relatively common alleles of small effect and some rare alleles with relatively large effects. Genome-wide association studies have identified at least one common allele of small effect at ZNF804a, which encodes a putative zinc finger binding protein, as well as possible roles for other loci. The genome-wide studies of at least one class of relatively uncommon variant, submicroscopic chromosomal abnormalities often referred to as copy number variations (CNVs), suggest that these confer high risk of schizophrenia. There is evidence both for an increased burden of CNVs in schizophrenia and that risk is conferred by specific large deletions at 1q21.1 and at 15q13.2 and by deletions of NRXN1 which encodes the synaptic scaffolding protein neurexin 1.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG) Neuroscience and Mental Health Research Institute (NMHRI)
Subjects:	Q Science > QH Natural history > QH426 Genetics R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Publisher:	Elsevier
ISSN:	0959-437X
Last Modified:	19 Oct 2022 10:42
URI:	https://orca.cardiff.ac.uk/id/eprint/25270

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