The additional costs of antibiotics and re-consultations for antibiotic-resistant Escherichia coli urinary tract infections managed in general practice

Alam, M. Fasihul, Cohen, David, Butler, Christopher Collett ORCID: https://orcid.org/0000-0002-0102-3453, Dunstan, Frank David John ORCID: https://orcid.org/0000-0002-1043-5281, Roberts, Zoe Elizabeth Sara, Hillier, Sharon and Palmer, Stephen Royston 2009. The additional costs of antibiotics and re-consultations for antibiotic-resistant Escherichia coli urinary tract infections managed in general practice. International Journal of Antimicrobial Agents 33 (3) , pp. 255-257. 10.1016/j.ijantimicag.2008.08.027

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Abstract

The emergence of antibiotic resistance is a major threat to public health. In the UK, most antibiotics are prescribed in general practice but the extra costs to general practice of resistant infections have not previously been well described. We compared the costs of treating patients presenting with resistant Escherichia coli urinary tract infections (UTIs) (resistant to ampicillin, trimethoprim or at least one antibiotic) with the costs of treating patients with UTIs that were sensitive to all six tested antibiotics (ampicillin, trimethoprim, amoxicillin/clavulanic acid, cefalexin, ciprofloxacin and nitrofurantoin) with regard to re-consultations and antibiotics prescribed. There were significantly higher antibiotic costs (mean extra antibiotic cost £1.19/€1.75), re-consultation costs (£2.42/€3.55) and total costs (£3.62/€5.31) for patients whose infections were resistant to at least one antibiotic compared with those with sensitive infections even after accounting for potentially confounding factors. Although these per-patient costs may appear small, they do not take into account the full additional costs of resistant UTIs in the community and, given the high prevalence of UTIs, the overall costs to the health service are substantial.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine Systems Immunity Research Institute (SIURI)
Subjects:	R Medicine > RA Public aspects of medicine > RA0421 Public health. Hygiene. Preventive Medicine
Uncontrolled Keywords:	cost, antibiotic resistance, general practice
Publisher:	Elsevier
ISSN:	0924-8579
Last Modified:	19 Oct 2022 10:42
URI:	https://orca.cardiff.ac.uk/id/eprint/25285

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